Topical calcineurin inhibitors

Topical calcineurin inhibitors as the name implies, block the activation of calcineurin, which is critical in the activation of lymphocytes, which are stimulated in autoimmune diseases. There are two types of topical treatments pimecrolimus and tacrolimus. These are ideal for areas such as the face, eyelids, neck, armpits and groin where there are concerns that topical steroids may cause side effects such as skin thinning and stretch marks. Topical calcineurin inhibitors take several months to elicit a positive effect